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| Shinde,Ravikumar Bapurao; Raut,Jayant Shankar; Chauhan,Nitin Mahendra; Karuppayil,Sankunny Mohan. |
| Biofilms formed by Candida albicans, a human pathogen, are known to be resistant to different antifungal agents. Novel strategies to combat the biofilm associated Candida infections like multiple drug therapy are being explored. In this study, potential of chloroquine to be a partner drug in combination with four antifungal agents, namely fluconazole, voriconazole, amphotericin B, and caspofungin, was explored against biofilms of C. albicans. Activity of various concentrations of chloroquine in combination with a particular antifungal drug was analyzed in a checkerboard format. Growth of biofilm in presence of drugs was analyzed by XTT-assay, in terms of relative metabolic activity compared to that of drug free control. Results obtained by XTT-metabolic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antifungal; Biofilm; Candida albicans; Combination; Chloroquine; Drug resistance. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400002 |
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| GIOVANELLA,FRANCIANNE; FERREIRA,GABRIELA K.; PRÁ,SAMIRA D.T. DE; CARVALHO-SILVA,MILENA; GOMES,LARA M.; SCAINI,GISELLI; GONÇALVES,RENATA C.; MICHELS,MONIQUE; GALANT,LETÍCIA S.; LONGARETTI,LUIZA M.; DAJORI,ANA LUIZA; ANDRADE,VANESSA M.; DAL-PIZZOL,FELIPE; STRECK,EMILIO L.; SOUZA,RENAN P. DE. |
| Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Primaquine; Chloroquine; Oxidative damage; DNA damage; Antimalarial drugs. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301487 |
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